Infection with gut parasites correlates with gut microbiome diversity across human populations in Africa.

Ngwese MM, Adegbite BR, Zinsou JF, Fitzstevens JL, Schmidt VT, Moure PAN, Maloum MN, Tyakht AV, Huus KE, Youngblut ND, Kremsner PG, Adegnika AA, Ley RE

Gut Microbes. 

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Dietary fat disrupts a commensal-host lipid network that promotes metabolic health.

Klag K, Ott D, Tippetts TS, Nicolson RJ, Tatum SM, Bauer KM, Stephen-Victor E, Weis AM, Bell R, Weagley J, Maschek JA, Vu DL, Heaver S, Ley RE, O’Connell R, Holland WL, Summers SA, Stephens WZ and Round JL.

Cell Metabolism. 

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Selection and transmission of the gut microbiome alone can shift mammalian behavior.

Suzuki TA, Akbuğa-Schön T, Waters JL, Jakob D, Vu DL, Ballinger MA, Di Rienzi SC, Chang H, de Araujo IE, Tyakht AV and Ley RE.

Nature Communications. 

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Carbohydrates and the oxidative branch of the pentose phosphate pathway modify Bacteroides thetaiotaomicron phage resistance by phase-variable S-layers.

Fuentes JJ, Singh S, Pudlo NA, Heaver SL, Ley RE and Martens EC.

Journal of Bacteriology. 

e00178-25. 

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Class switch towards IgG2 and IgG4 is more pronounced in BNT162b2 compared to mRNA-1273 COVID-19 vaccinees.

Siebner AS, Griesbaum J, Huus KE, Flügge J, Hopfensperger K, Michel T, Schneiderhan-Marra N, Sauter D, Kremsner PG, Ley RE, Dulovic A and Esen M.

International Journal of Infectious Diseases. 

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Tracking gene order provides a new perspective on intraspecific evolution in microbiotas.

Enav H and Ley RE.

Nature Biotechnology. 

43: 698–699. 

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DOI: https://doi.org/10.1038/s41587-024-02277-1

Strain tracking in complex microbiomes using synteny analysis reveals per-species modes of evolution.

Enav H, Paz I and Ley RE.

Nature Biotechnology. 

43: 773–783. 

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Clinical translation of microbiome research.

Gilbert  JA, Azad  MB, Bäckhed F, Blaser MJ, Byndloss M, Chiu CY, Chu H, Dugas LR, Elinav E, Gibbons SM, Gilbert KE, Henn MR, Ishaq SL, Ley  RE, Lynch SV, Segal E, Spector TD, Strandwitz P, Suez J, Tropini C, Whiteson K and Knight R.

Nature Medicine. 

31:1099–1113. 

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DOI: https://doi.org/10.1038/s41591-025-03615-9

Cross-kingdom-mediated detection of intestinal protozoa through NLRP6.

Winsor NJ, Bayer G, Singh O, Chan JK, Li LY, Lieng BY, Foerster E, Popovic A, Tsankov BK, Maughan H, Lemire P, Tam E, Streutker C, Chen L, Heaver SL, Ley RE, Parkinson J, Montenegro-Burke JR, Birchenough GMH, Philpott DJ and Girardin SE.

Cell Host & Microbe. 

33: 388 - 407.e9. 

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In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier.

Rytter H, Naimi S, Wu G, Lewis J, Duquesnoy M, Vigué L, Tenaillon O, Belda E, Vazquez-Gomez M, Touly N, Arnone D, Hao F, Ley RE, Clément K, Peyrin-Biroulet L, Patterson AD, Gewirtz AT and Chassaing B.

Gut. 

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DOI: https://gut.bmj.com/content/early/2025/01/13/gutjnl-2024-333925

Medication use is associated with distinct microbial features in anxiety and depression.

Dilmore AH, Kuplicki R, McDonald D, Kumar M, Estaki M, Youngblut N, Tyakht A, Ackermann G, Blach C, MahmoudianDehkordi S, Dunlop BW, Bhattacharyya S, Guinjoan S, Mandaviya P, Ley RE, Kaddaruh-Dauok R, Paulus MP and Knight R; Alzheimer Gut Microbiome Project Consortium.

Molecular Psychiatry. 

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DOI: https://doi.org/10.1038/s41380-024-02857-2