We are interested in the co-evolution of humans with their microbiomes

We do basic science related to the evolutionary history of gut microbes and how they have adapted to life inside humans.

Learn more Publications

Latest News

Ruth was elected to the Leopoldina (German National Academy of Sciences) in June.

The Leopoldina originated in 1652 as a classical scholarly society...

We know from previous work that people with a lactase-non-persistent (LNP) genotype have more Bifidobacteria in their guts, but what kinds? Victor...

Here Nick Youngblut uses tree-based approaches for comparing human gut metagenomes. This is similar to using UniFrac for 16S rRNA datasets. And...

Selected Publications

Johnson EL, Heaver SL, Waters JL, Kim BI, Bretin A, Goodman AL, Gewirtz AT, Worgall TS and Ley RE. Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels. Nature Communications 11:2471 (2020)

Ruaud A, Esquivel-Elizondo S, de la Cuesta-Zuluaga J, Waters JL,  Angenent LT, Youngblut ND and Ley RE: Syntrophy via interspecies H2 transfer between Christensenella and Methanobrevibacter underlies their global co-occurrence in the human gut. mBio, 11 e03235-19 (2020)

Youngblut ND, Reischer GH, Walters W, Schuster N, Walzer C, Stalder, G, Ley RE and Farnleitner AH: Host diet and evolutionary history explain different aspects of gut microbiome diversity among vertebrate clades. Nature Communications 10: 2200. (2019)

Poole AC, Goodrich JK, Youngblut ND, Luque GG, Ruaud A, Sutter JL, Waters JL, Shi Q, El-Hadidi M, Johnson LM, Bar HY, Huson DH, Booth JG and Ley RE : Human salivary amylase gene copy number impacts oral and gut microbiomes. Cell Host & Microbe 25: 553-564 (2019).

Moreno-Gallego JL, Chou SP, Di Rienzi SC, Goodrich JK, Spector T, Bell JT, Youngblut N, Hewson I, Reyes A and Ley RE: Virome diversity correlates with intestinal microbiome diversity in adult monozygotic twins. Cell Host & Microbe 25: 261-272. (2019).

Goodrich JK, Davenport ER, Waters JL, Clark AG and Ley RE: Cross-species comparisons of host genetic associations with the microbiome. Science 352: 532-535. (2016).

Goodrich JK, Waters JL, Poole AC, Sutter JL, Koren O, Blekhman R, Beaumont M, Van Treuren W, Knight R, Bell JT, Spector TD, Clark AG and Ley RE: Human genetics shape the gut microbiome. Cell 159: 789-799. (2014).