We are interested in the co-evolution of humans with their microbiomes

Our basic science investigates the evolutionary history of gut microbes, how they have adapted to life inside humans, and how they affect human biology and health.

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Latest News

Our new paper on the evolutionary histories of the human gut microbiota is out in Science. The work was led by Taichi Suzuki and Liam Fitzstevens...

Congratulations to Ruth Ley, who was awarded a certificate in recognition of her induction into the Leopoldina Academy during the annual ceremony held...

Our new pre-print is up on bioRxiv! Led by Nicholas Youngblut, this work presents ResMiCo, a powerful tool for optimising metagenome assemblies.

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Congrats to Stacey Heaver for publishing her work on inositol lipid metabolism in Nature Microbiology.

Selected Publications

Suzuki TA, Fitzstevens JL, Schmidt VT, Enav H, Huus KE, Mbong Ngwese M, Grießhammer A, Pfleiderer A, Adegbite BR, Zinsou JF, Esen M, Velavan TP, Adegnika AA, Song LH, Spector TD, Muehlbauer AL, Marchi N, Kang H, Maier L, Blekhman R, Ségurel L, Ko G, Youngblut ND, Kremsner P, Ley RE. Codiversification of gut microbiota with humans. Science: 16;377(6612):1328-1332. doi: 10.1126/science.abm7759. (2022). (PDF)

Heaver, S. L., H H. Le, P. Tang, A. Baslé, C. Mirretta Barone, D. Long Vu, J. L. Waters, J. Marles-Wright, E. L. Johnson, D. J. Campopiano & R. E. Ley. Characterization of inositol lipid metabolism in gut-associated Bacteroidetes. Nature Microbiologyhttps://doi.org/10.1038/s41564-022-01152-6 (2022)

Youngblut ND, Reischer GH, Dauser S, Maisch S, Walzer C, Stalder G, Farnleitner AH, Ley RE. Strong influence of vertebrate host phylogeny on gut archaeal diversity. Nature Microbiology 6: 443–1454 https://rdcu.be/cP3JC (2021)

Suzuki T and Ley RE. The role of the microbiota in human genetic adaptation. Science 370 eaaz6827 (2020)

Johnson EL, Heaver SL, Waters JL, Kim BI, Bretin A, Goodman AL, Gewirtz AT, Worgall TS and Ley RE. Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels. Nature Communications 11:2471 (2020)