We are interested in the co-evolution of humans with their microbiomes

We do basic science related to the evolutionary history of gut microbes and how they have adapted to life inside humans.

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Latest News

Yestarday afternoon, we had a toast for Priyanka, a reasearch technician who is leaving the lab in a few days. All the best to her. And of course we...

Today our new pre-print was published on bioRxiv! Shining a spotlight on two of our favorite bugs, we show that co-occurence of Christensenella and Me...

2019 is comming to an end, but the holidays are not the only reason to celebrate in the Ley Lab; we close the year with three new publicatons!

First,...

Selected Publications

Johnson E. L., Heaver S. L., Waters J. L., Kim B. I., Bretin A., Goodman A. L., Gewirtz A. T., Worgall, T. S. and R. E. Ley. Sphingolipid production by gut Bacteroidetes regulates glucose homeostasis. bioRxiv 632877; doi: https://doi.org/10.1101/632877 (2019)

Poole A. C., Goodrich J. K., Youngblut N. D., Luque G. G., Ruaud A., Sutter J. L., Waters J. L., Shi Q., El-Hadidi M., Johnson L. M., Bar H. Y., Huson D. H., Booth J. G. and R. E. Ley : Human salivary amylase gene copy number impacts oral and gut microbiomes. Cell Host & Microbe 25: 553-564 (2019).

Moreno-Gallego J. L., Chou S. P., Di Rienzi S. C., Goodrich J. K., Spector T., Bell J. T., Youngblut N., Hewson I., Reyes A. and R. E. Ley : Virome diversity correlates with intestinal microbiome diversity in adult monozygotic twins. Cell Host & Microbe 25: 261-272. (2019).

Walters W. A., Jin Z., Youngblut N., Wallace J. G., Sutter J., Zhang W., González-Peña A., Peiffer J., Koren  O., Shi  Q., Rob Knight, Glavina del Rio T., Tringe S. G., Buckler E. S., Dangl J. L., and R. E. Ley Large-scale replicated field study of maize rhizosphere identifies heritable microbes. Proceedings of the National Academy of Sciences USA pii: 201800918 (2018).

Goodrich, J. K., E. R. Davenport, J. L. Waters, A. G. Clark and R. E. Ley. Cross-species comparisons of host genetic associations with the microbiome. Science 352: 532-535. (2016).

Goodrich, J. K.,  J. L. Waters, A. C. Poole, J. L. Sutter, O. Koren, R. Blekhman, M. Beaumont, W. Van Treuren, R. Knight, J. T. Bell, T. D. Spector, A. G. Clark and R. E. Ley. Human genetics shape the gut microbiome. Cell 159: 789-799. (2014).

Cullender T. C., Chassaing B., Janzon A., Kumar K., Muller C., Werner J. J., Angenent L. T., Bell M. E., Hay A. G., Peterson D. A., Walter J., Vijay-Kumar M., Gewirtz A. T. and R. E. Ley. Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe 14: 571-581. (2013).

Di Rienzi S. C., Sharon I., Wrighton K. C., Koren O., Hug L. A., Thomas B. C., Goodrich J. K., Bell J. T., Spector T. D., Banfield J. F. and R. E. Ley. The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to Cyanobacteria. eLife 2:e01102. (2013).