We are interested in the co-evolution of humans with their microbiomes

We take an evolutionary perspective to ask how microbial communities in the gut adapted to life in the human host.

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Latest News

Congratulations to Ley Lab Group Leader, Nicholas Youngblut, and Postdoc William Walters, who saw their research on the vertebrate microbiome publishe...

Our new preprint was released today on bioRxiv! Interactions between the gut microbiome and mucosal immunoglobulins A, M and G in the developing...

Our paper on age- and sex-dependent microbial diversity is out! Titled Age- and Sex-Dependent Patterns of Gut Microbial Diversity in Human Adults,...

Selected Publications

Johnson E. L., Heaver S. L., Waters J. L., Kim B. I., Bretin A., Goodman A. L., Gewirtz A. T., Worgall, T. S. and R. E. Ley. Sphingolipid production by gut Bacteroidetes regulates glucose homeostasis. bioRxiv 632877; doi: https://doi.org/10.1101/632877 (2019)

Poole A. C., Goodrich J. K., Youngblut N. D., Luque G. G., Ruaud A., Sutter J. L., Waters J. L., Shi Q., El-Hadidi M., Johnson L. M., Bar H. Y., Huson D. H., Booth J. G. and R. E. Ley : Human salivary amylase gene copy number impacts oral and gut microbiomes. Cell Host & Microbe 25: 553-564 (2019).

Moreno-Gallego J. L., Chou S. P., Di Rienzi S. C., Goodrich J. K., Spector T., Bell J. T., Youngblut N., Hewson I., Reyes A. and R. E. Ley : Virome diversity correlates with intestinal microbiome diversity in adult monozygotic twins. Cell Host & Microbe 25: 261-272. (2019).

Walters W. A., Jin Z., Youngblut N., Wallace J. G., Sutter J., Zhang W., González-Peña A., Peiffer J., Koren  O., Shi  Q., Rob Knight, Glavina del Rio T., Tringe S. G., Buckler E. S., Dangl J. L., and R. E. Ley Large-scale replicated field study of maize rhizosphere identifies heritable microbes. Proceedings of the National Academy of Sciences USA pii: 201800918 (2018).

Goodrich, J. K., E. R. Davenport, J. L. Waters, A. G. Clark and R. E. Ley. Cross-species comparisons of host genetic associations with the microbiome. Science 352: 532-535. (2016).

Goodrich, J. K.,  J. L. Waters, A. C. Poole, J. L. Sutter, O. Koren, R. Blekhman, M. Beaumont, W. Van Treuren, R. Knight, J. T. Bell, T. D. Spector, A. G. Clark and R. E. Ley. Human genetics shape the gut microbiome. Cell 159: 789-799. (2014).

Cullender T. C., Chassaing B., Janzon A., Kumar K., Muller C., Werner J. J., Angenent L. T., Bell M. E., Hay A. G., Peterson D. A., Walter J., Vijay-Kumar M., Gewirtz A. T. and R. E. Ley. Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe 14: 571-581. (2013).

Di Rienzi S. C., Sharon I., Wrighton K. C., Koren O., Hug L. A., Thomas B. C., Goodrich J. K., Bell J. T., Spector T. D., Banfield J. F. and R. E. Ley. The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to Cyanobacteria. eLife 2:e01102. (2013).