Wir interessieren uns für die Koevolution von Menschen und deren Mikrobiomen

Mit einem evolutionären Ansatz stellen wir die Frage, wie sich die Gemeinschaften von Mikroorganismen im Darm an das Leben im menschlichen Wirt anpassten.

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Congratulations to all doctoral students that presented their work, especially Andrea Borbon, Mirabeau Mbong, and Yihua Liu who were also recognized...

In this YouTube video, Nick Youngblut and colleagues discuss their latest work on the Archaea of the vertebrate gut.

Read the original research paper...

Archaea are often mistaken as bacteria, given that both are small, single-cell organisms. However, archaea are as genetically different from bacteria...

Ausgewählte Veröffentlichungen

Suzuki T and Ley RE. The role of the microbiota in human genetic adaptation. Science 370 eaaz6827 (2020)

Johnson EL, Heaver SL, Waters JL, Kim BI, Bretin A, Goodman AL, Gewirtz AT, Worgall TS and Ley RE. Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels. Nature Communications 11:2471 (2020)

Ruaud A, Esquivel-Elizondo S, de la Cuesta-Zuluaga J, Waters JL,  Angenent LT, Youngblut ND and Ley RE: Syntrophy via interspecies H2 transfer between Christensenella and Methanobrevibacter underlies their global co-occurrence in the human gut. mBio, 11 e03235-19 (2020)

Youngblut ND, Reischer GH, Walters W, Schuster N, Walzer C, Stalder, G, Ley RE and Farnleitner AH: Host diet and evolutionary history explain different aspects of gut microbiome diversity among vertebrate clades. Nature Communications 10: 2200. (2019)

Poole AC, Goodrich JK, Youngblut ND, Luque GG, Ruaud A, Sutter JL, Waters JL, Shi Q, El-Hadidi M, Johnson LM, Bar HY, Huson DH, Booth JG and Ley RE : Human salivary amylase gene copy number impacts oral and gut microbiomes. Cell Host & Microbe 25: 553-564 (2019).

Moreno-Gallego JL, Chou SP, Di Rienzi SC, Goodrich JK, Spector T, Bell JT, Youngblut N, Hewson I, Reyes A and Ley RE: Virome diversity correlates with intestinal microbiome diversity in adult monozygotic twins. Cell Host & Microbe 25: 261-272. (2019).

Goodrich JK, Waters JL, Poole AC, Sutter JL, Koren O, Blekhman R, Beaumont M, Van Treuren W, Knight R, Bell JT, Spector TD, Clark AG and Ley RE: Human genetics shape the gut microbiome. Cell 159: 789-799. (2014).