Our recent discovery of silent flagellin in the human gut was featured in Science Immunology:
- Hannah Baer, Shruti Sandilya and Theodore Steiner: Evading the Toll Booth: How “silent” flagellin may bind yet fail to activate TLR5
The nature of flagellin–Toll-like receptor 5 (TLR5) interactions, depending on binding to and activation of TLR5, may hold a key to the distinct differences in gut microbiome and intestinal immune function in different populations around the world.