We are interested in the co-evolution of humans with their microbiomes

We take an evolutionary perspective to ask how microbial communities in the gut adapted to life in the human host.

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Latest News

The last issue of Cell Host and Microbe is dedicated to phages and includes our study on viruses in the human gut. This paper shows how we examined...

Curious about your gut microbiome and how you digest lactose? We’re looking for hundreds more mothers to participate at our partnering Institute of...

Leonardo Moreno -a PhD student from our lab- and colleagues have recently published on BioRxiv a research article on the relationship between...

Selected Publications

Poole A.C., Goodrich J.K., Youngblut N.D., Luque G.G., Ruaud A., Sutter J.L., Waters J.L., Shi Q., El-Hadidi M., Johnson L.M., Bar H.Y., Huson D.H., Booth J.G. and R.E. Ley. Human salivary amylase gene copy number impacts oral and gut microbiomes. Cell Host & Microbe (In Press).

Moreno-Gallego J. L., Chou S. P., Di Rienzi S. C., Goodrich J. K., Spector T., Bell J. T., Youngblut N., Hewson I., Reyes A. and R. E. Ley : Virome diversity correlates with intestinal microbiome diversity in adult monozygotic twins. Cell Host & Microbe 25: 261-272. (2019).

Walters W. A., Jin Z., Youngblut N., Wallace J. G., Sutter J., Zhang W., González-Peña A., Peiffer J., Koren  O., Shi  Q., Rob Knight, Glavina del Rio T., Tringe S. G., Buckler E. S., Dangl J. L., and Ley R. E. Large-scale replicated field study of maize rhizosphere identifies heritable microbes. Proceedings of the National Academy of Sciences USA pii: 201800918 (2018).

Goodrich, J. K. , E. R. Davenport, M. A. Jackson, M. Beaumont, R. Knight, T. D. Spector, J. T. Bell, A. G. Clark, R. E. Ley. Genetic determinants of the gut microbiome assessed in UK Twins. Cell Host & Microbe 19:731-43. (2016).

Goodrich, J. K., E. R. Davenport, J. L. Waters, A. G. Clark and R. E. Ley. Cross-species comparisons of host genetic associations with the microbiome. Science 352: 532-535. (2016).

Goodrich, J. K.,  J. L. Waters, A. C. Poole, J. L. Sutter, O. Koren, R. Blekhman, M. Beaumont, W. Van Treuren, R. Knight, J. T. Bell, T. D. Spector, A. G. Clark and R. E. Ley. Human genetics shape the gut microbiome. Cell 159: 789-799. (2014).